Identification of Honey Flavonoids as Potential Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase and Main Protease: An In silico Analysis

COVID-19 caused by SARS-CoV-2 is a serious health crisis worldwide and requires safe efficacious treatment to combat the disease. RNA-dependent RNA polymerase (RdRp) main protease (Mpro) are vital enzymes in life cycle considered effective drug targets. In current investigation, fourteen (14) flavonoids from honey were assessed analyze their potential for RdRp Mpro inhibition using computational approach. First, screened based on drug-likeness, which determined all compounds except epigallocatechin gallate as orally bioavailable drugs with easy absorbance high permeability. Screened thirteen (13) subjected molecular docking analysis identify potent inhibitors of target proteins (RdRp Mpro). The revealed significant binding affinities both proteins. Luteolin showed most stable interactions (−7.6 kcal/mol) while apigenin kaempferol displayed energy −7.8 kcal/mol Mpro. Low energies indicate these compounds' Toxicity depicted top prediction probability accuracy human body. findings predict anti-COVID-19 where inhibitor exhibit good pharmacodynamics properties accuracy. Further wet-lab experiments involving vitro vivo assays recommended investigate effectiveness cure COVID-19.